منابع مشابه
Gamma-Herpesvirus Latency Requires T Cell Evasion during Episome Maintenance
The gamma-herpesviruses persist as latent episomes in a dynamic lymphocyte pool. Their consequent need to express a viral episome maintenance protein presents a potential immune target. The glycine-alanine repeat of the Epstein-Barr virus episome maintenance protein, EBNA-1, limits EBNA-1 epitope presentation to CD8(+) T lymphocytes (CTLs). However, CTL recognition occurs in vitro, so the signi...
متن کاملMetastatic Latency and Immune Evasion through Autocrine Inhibition of WNT
Metastasis frequently develops years after the removal of a primary tumor, from a minority of disseminated cancer cells that survived as latent entities through unknown mechanisms. We isolated latency competent cancer (LCC) cells from early stage human lung and breast carcinoma cell lines and defined the mechanisms that suppress outgrowth, support long-term survival, and maintain tumor-initiati...
متن کاملViral Bcl-2-Mediated Evasion of Autophagy Aids Chronic Infection
c-herpesviruses (cHVs) have developed an interaction with their hosts wherein they establish a life-long persistent infection and are associated with the onset of various malignancies. One critical virulence factor involved in the persistency of murine c-herpesvirus 68 (cHV68) is the viral homolog of the Bcl-2 protein (vBcl-2), which has been implicated to counteract both host apoptotic respons...
متن کاملHerpesviral-bacterial interactions in periodontal diseases.
Periodontitis is one of the most complex infectious diseases of the human body. Individual periodontal lesions may harbor millions of genomic copies of herpesviruses (179) as well as papillomaviruses, human immunodeficiency virus (HIV), human T-lymphotropic virus type 1, torquetenovirus, and hepatitis B and C viruses (190). Herpesvirus-infected periodontal sites tend to exhibit more breakdown t...
متن کاملPrimary gamma-herpesviral infection in Zambian children
BACKGROUND HHV-8 is closely related to Epstein-Barr virus (EBV), but the clinical presentations of these two infections in early childhood are not well understood. Also, it is not known whether infection by one virus correlates with another. Here, we compare the natural history of infection by these two viruses along with the clinical manifestations and risk factors that are associated with ear...
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ژورنال
عنوان ژورنال: Autophagy
سال: 2010
ISSN: 1554-8627,1554-8635
DOI: 10.4161/auto.6.1.10536